Obesity and Diseases

November 06, 2017
Home 9 Obesity Conditions 9 Obesity and Diseases

Obesity is a major risk factor in the development of many diseases. New research suggests that greater than 2/3 of the United States of America’s population is either overweight or obese. Controlling the underlying cause (obesity) is instrumental in the treatment and prevention of these conditions.  Below is a brief listing of common comorbid conditions.

Insulin Resistance & Type II Diabetes

Diabetes is an international epidemic whose etiology is linked to obesity; therefore a first line effort in preventing, managing and treating Type II Diabetes is losing weight. A myriad of studies show that modest weight loss helps increase metabolic control and minimize the effects, both short and long term, of the disease. Recent guidelines and clinical evidence recommend the need for proper nutrition and weight loss as critical components of treatment goals (Glycemic, Blood Pressure and Lipid control). It’s well studied that Very Low Calorie Diets (VLCD) can help patients achieve all three. Diet-induced weight loss can help improve beta-cell function by mobilizing surrounding fat (an underlying cause of Type II Diabetes), improving blood pressure, and decreasing blood cholesterol all within seven days of starting a VLCD. Ultimately, long term control via weight loss and lifestyle management results in improving metabolic control, quality of life measures as well as reducing and/or eliminating medications.     


Hypertension, or high blood pressure, affects just about one third of those living in America, with those who are overweight or obese being at highest risk. Hypertension is most often controlled through lifestyle modification (diet and exercise) and medication, if necessary. The clinical evidence demonstrates that the following list of lifestyle modifications greatly reduces your risk: weight loss, exercise, decreased sodium intake, meditation/mindfulness practice and smoking cessation (if currently using tobacco products). As a result of weight loss from a VLCD, patients experience up to a 10% reduction in risk of stroke, hypertension and atrial fibrillation.


Dyslipidemia is defined as an abnormality of blood lipids, or blood fats such as triglycerides and cholesterol. The most common dyslipidemia associated with obesity is elevated triglycerides, typically a result of the accompanying insulin resistance. When patients start a VLCD there are tremendous clinical improvements with a reduction in triglycerides, and long-term maintenance shows an improvement in overall blood lipid profile. Most patients who are successful with weight loss will also experience a reduction, if not elimination, of medications used to control their dyslipidemia.

Cardiovascular Disease

Cardiovascular disease is the general term for diseases of the heart and circulatory system. It’s well known that as BMI increases the incidences of Coronary Heart Disease (CHD), Congestive Heart Failure (CHF), Stroke, Atrial Fibrillation (AF) and Deep Vein Thrombosis (DVT) also increase. Fortunately, clinical research has established that even mild weight loss while following a VLCD (about 5% loss in baseline) demonstrates a clinically significant reduction in blood pressure, improvements to both blood lipids and insulin sensitivity. Changes in each of these markers will prove beneficial to overall risk of cardiovascular disease.

Sleep Apnea

Sleep apnea is a medical disorder characterized by one or more pauses of breath or shallow breathings during sleep. These pauses last for mere moments or sometimes longer. Obesity related sleep apnea (Obstructive Sleep Apnea) occurs when extra tissue slides over the airway, obstructing and disturbing sleep. This is often a chronic (ongoing) issue and, when undiagnosed can increase risk of hypertension, stroke, diabetes and heart attack. While there are medical interventions such as c-pap breathing machines, the first real line of defense is weight loss, and one clinical proven way of losing weight is following a VLCD.


Over 80,000 cases of cancer diagnoses are directly related to obesity. In fact, obesity and overweight is connected to up to 20% of total yearly cancer diagnoses. Some associated cancers with great risk are colon cancer, postmenopausal breast cancer and cancers of the gallbladder, pancreas, kidney, prostate and esophagus. Obesity can affect the therapies used to treat these cancers and also raises the overall risk of second malignancies. A primary method to help reduce the overall risk and help with treatments is following a VLCD to help facilitate weight loss and work to adopt healthier lifestyle choices that includes more daily physical activity.


Lin Yang, Graham A. Colditz. Prevalence of Overweight and Obesity in the United States, 2007-2012. JAMA Internal Medicine, 2015; DOI: 10.1001/jamainternmed.2015.2405
AACE Comprehensive Diabetes Management Algorithm. Endocrinology Practice. 2013;19:327-336
Nutrition Therapy Recommendations for the Management of Adults with Diabetes. Diabetes Care, 2013
Kelley DE, Wing R, Buonocore C, Sturis J, Polonsky K, Fitzsimmons M. Relative effects of calorie restriction and weight loss in noninsulin-dependent diabetes mellitus. Journal of Clinical Endocrinology Metabolism. 1993;77:1287-93
Lim EL, Hollingsworth KG, Aribisala BS, Chen MJ, Mathers JC, and Taylor R. Reversal of type 2 diabetes: normalization of beta cell function in association with decreased pancreas and liver triacycerol. Diabetologia. 2011 Oct;54(10):2506-14
Wing RR, Lang W, Wadden TA, Safford M, Knowler WC, Bertoni AG, Hill JO, Brancati FL, Peters A, Wagenknecht L; Look AHEAD Research Group. Benefits of modest weight loss in improving cardiovascular risk factors in overweight and obese individuals with type 2 diabetes. Diabetes Care 2011;34:1481-86
Case CC, Jones PH, Nelson K, O’Brian Smith E, Ballantyne CM. Impact of weight loss on the metabolic syndrome. Diabetes Obesity Metabolism. 2002 Nov;4(6):402-6
de Mello VD, Lindström J, Eriksson J, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Sundvall J, Laakso M, Tuomilehto J, Uusitupa M. Insulin secretion and its determinants in the progression of impaired glucose tolerance to type 2 diabetes in impaired glucose-tolerant individuals. Diabetes Care 2012;35: 211-17

Jonathan M. McGavock, PhD; Ronald G. Victor, MD; Roger H. Unger, MD; and Lidia S. Szczepaniak, PhD1. Adiposity of the Heart*, Revisited. Annuals of Internal Medicine 2006;144:517
Shah RV, Abbasi SA, Neilan TG, Hulten E, Coelho-Filho O, Hoppin A, Levitsky L, de Ferranti S, Rhodes ET, Traum A, Goodman E, Feng H, Heydari B, Harris WS, Hoefner DM, McConnell JP, Seethamraju R, Rickers C, Kwong RY, Jerosch-Herold M. Myocardial tissue remodeling in adolescent obesity. J Am Heart Assoc 2013;2:e000279 doi:10.1161/JAHA.113.000279
Peterson LR, Waggoner AD, Schectman KB, et al. Alterations in left ventricular structure and function in young healthy obese women: assessment by echocardiography and tissue Doppler imaging. American College of Cardiology 2004;43:1399–404
Very-Low-Calorie Diet Improves Diabetic Heart Function. Radiological Society of North America 2011; abstract SSE04-06
von Bibra H, Wulf G, Pfützner A, Schumm-Draeger P-M. A low glycemic/insulinemic diet improves diastolic cardiac function and metabolic syndrome more than the traditional low-fat diet in overweight patients with type 2 diabetes. Pre-diabetes and the Metabolic Syndrome 2013 Congress; April 19, 2013; Vienna, Austria. Abstract 852